Rosai-Dorfman disease (RD) Donate Sinus Histiocytosis with Massive Lymphadenopathy (SHML) Rosai-Dorfman disease (RD), also known as sinus Histiocytosis with massive lymphadenopathy (SHML), is a rare histiocytic disorder which involves the over-production of a type of white blood cell called non-Langerhans-cell sinus histiocytes. These cells then accumulate, most often in the lymph nodes but sometimes in … Continue reading Rosai-Dorfman disease (RD)