How your company can help

Histiocytosis touches the lives of not just children, young people and adults, but parents, siblings, aunts and uncles, schools, friends and the wider community. Our cause will resonate with your staff, your customers and your clients.

Charity partnerships
We can help your company achieve its corporate social responsibility and marketing objectives whilst offering excellent fundraising, PR and team opportunities. We have fundraising for all to get involved in, from 60-mile challenges, abseils and overseas treks to cake bakes, swap shops and fancy dress days! We will work with you to develop an exciting calendar of events and a communication plan to help us maximize the partnership potential.

Corporate Sponsors (download our Corporate Sponsorship brochure here)

There is just one piece of the puzzle missing!
Despite the misery it causes, Histiocytosis is too rare a disease to have generated substantial
research in medical circles. Unfortunately, for every child or adult fighting for his or her life, the pain and suffering are just as severe for children and adults afflicted with other better known disorders receiving funding.

For the children and adults battling these illnesses, there is now reason to hope. To ensure the
research continues, we ask for your help, to complete the funding puzzle.

Our research programmes provide a beacon of hope for the many children and adults battling
Histiocytosis, to ensure this research continues we ask you to pledge your support.

Our Research Goals
 To facilitate the development of gene therapy for HLH patients
 To further research on genetic changes in LCH
 To proceed to clinical trials of drugs targeted to the BRAF mutation

Our Objectives
 The promotion and furtherance of scientific research into the physiology and pathology of histiocytes and the aetiology of histiocytocytic diseases.
 The development of more accurate means of diagnosis, improved protocols for management of patients and ultimately measures for prevention of histiocytic diseases.
 The provision of information in support of patients and families affected by histiocytosis.

Working In Partnership
2005-In 2005 we committed £150,000 funding a major three year research project at the University of Lausanne, Switzerland, led by Professor Hans Acha-Orbea. The aim of the project was to identify genes that are switched on when normal dendritic cells, which are closely related to Langerhans’ Cells, become tumours.

Outcomes
Professor Acha-Orbea used a virus to carry a tumour forming gene into mouse dendritic cells which went on to become dendritic cell tumours. He identified genes that are switched on or off as normal dendritic cells become dendritic cell tumours, and that might be targeted to kill abnormal dendritic cells. He plans to go on to search for these genes in human Langerhans Cell Histiocytosis samples. The cell lines continue to provide a resource for understanding normal and abnormal dendritic cells.

Steiner QG, Otten LA, Hicks MJ, Kaya G, Grosjean F, Saeuberli E, Lavanchy C, Beermann F, McClain KL, Acha-Orbea H. In vivo transformation of mouse conventional CD8alpha+ dendritic cells leads to progressive multisystem histiocytosis. Blood. 2008; 111: 2073-82.

Fuertes Marraco SA, Grosjean F, Duval A, Rosa M, Lavanchy C, Ashok D, Haller S, Otten LA, Steiner QG, Descombes P, Luber CA, Meissner F, Mann M, Szeles L, Reith W, Acha-Orbea H. Novel murine dendritic cell lines: a powerful auxiliary tool for dendritic cell research. Front Immunol. 2012; 3: 331.

2009-In 2009 we allocated £220,954 to fund a ground-breaking project with the Institute of Child Health at University College London. The project model investigated ways of introducing a normal Perforin gene – the gene most commonly affected inherited HLH – into white blood cells.

Outcomes
Professors Bobby Gaspar and Adrian Thrasher together with Dr. Marlene Carmo, who was funded by the grant, demonstrated that they can successfully introduce a normal perforin gene into mouse stem cells. These stem cells restore normal lymphocyte function when introduced into mice that have an abnormal perforin gene and usually develop HLH. Professors Caspar and Thrasher are now planning to develop this form of gene therapy to restore normal immune function in patients suffering from HLH.

2012-In 2012 we committed £327,000 over three years to a collaborative project at the Centre for Molecular and Cellular Biology of Inflammation, Kings College London and the Institute of Cellular Medicine, Newcastle, led by Professor Frederic Geissmann and Dr Matthew Collin.

The project will build on the recent important discovery of a genetic mutation in half of LCH samples tested.

Interim Update
Professor Geissmann and Dr Collin have made good progress in setting up the model system they will use to study signalling in BRAF V600E positive cells and this work is expected to identify additional molecules that may be drug targets. They have already identified new mutations in BRAF itself.

Satoh T, Smith A, Sarde A, Lu HC, Mian S, Trouillet C, Mufti G, Emile JF, Fraternali F, Donadieu J, Geissmann F. Apr 10B-RAF mutant alleles associated with Langerhans cell histiocytosis, a granulomatous pediatric disease. PLoS One. 2012; 7: e33891.

Payroll giving
Easy to set up and simple to manage, payroll giving is an effortless and tax-effective way for staff to support Histio UK help children, young people and adults with histiocytosis, and their families, the whole year round.

Event Sponsorship
Sponsorship is a fantastic way to support Histio UK whilst achieving a route to market and generating great brand awareness amongst your customers and our supporters.

Cause Related Marketing
CRM is a fantastic way to promote your brand and raise money and awareness for the vital information and research that Histio UK provides. Research from Business in the Community shows that 86% of consumers are more likely to buy a product that is associated with a cause or issue and 73% of consumers would switch brands. A CRM partnership with Histio UK will enable your company to connect with customers, gain a great presence in the community and engage with new audiences.

How we will support you
We will work closely with you to meet your aims and objectives.

Benefits for your company
Get involved in your community
• Link to a UK-wide charity
• Build deeper networks with your audience by providing direct support to the communities your company operates in

Motivate your colleagues
• Encourage team-building, boost employee morale and build loyalty
• Give employees the opportunity to take part in volunteering, expeditions and exciting events
• Engage your customers or clients in fundraising activities

Enhance your brand
• Build rapport with your target audience
• Reach a potential new audience
• Build your reputation as a socially responsible company
• Generate positive PR opportunities at a local and national level
• Be associated with a respected UK-wide charity

How to get involved
We would be delighted to hear from you if you want to discuss how your company can become involved. Please get in touch – call 07850 740241 or email histio@histiouk.org

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When we are out of the office and over holiday periods we have limited access to email and telephone. We will respond to your enquiry as soon as it is possible or upon our return. Thank You.

Telephone: 01733 309619 - Please note this is not a 24 hour number - 9am to 5.30pm

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